Frankfurt - Madrid arası en sık kullanılanan havayolu firmaları genelde
Scandinavian Airlines,
Air China,
Ethiopian Airlines,
Air Europa,
Air Nostrum,
Japan Airlines,
Aeromexico,
Lufthansa,
Air Baltic,
Austrian,
Delta Air Lines,
United Airlines,
Iberia,
Oman Air,
Lan Airlines,
Air Canada,
Finnair,
All Nippon Airways,
Singapore Airlines,
China Airlines,
Etihad Airways,
Vietnam Airlines,
Air Serbia,
Condor,
Avianca,
LOT Polish Airlines
firmalarıdır.