As companhias aéreas mais utilizadas entre Lizbon e Madrid são geralmente
American Airlines,
Egyptair,
SATA International,
Aeromexico,
Delta Air Lines,
easyJet,
Japan Airlines,
Vueling Airlines,
El Al Israel Airlines,
Aegean Airlines,
Azul Linhas Aereas Brasileiras,
Tarom,
Finnair,
TAP Portugal,
Iberia,
Air Europa,
Lan Airlines,
Air Canada,
Qatar Airways,
Saudi Arabian Airlines,
Avianca,
Bulgaria Air,
United Airlines,
Portugalia,
Air Serbia
empresas.