As companhias aéreas mais utilizadas entre Frankfurt e Madrid são geralmente
Ethiopian Airlines,
Lufthansa,
Austrian,
United Airlines,
Aeromexico,
Oman Air,
Air Baltic,
Delta Air Lines,
Lan Airlines,
All Nippon Airways,
Iberia,
Singapore Airlines,
Air Canada,
Vietnam Airlines,
Finnair,
Air Serbia,
Condor,
China Airlines,
Etihad Airways,
LOT Polish Airlines,
Scandinavian Airlines,
Air Europa,
Avianca,
Japan Airlines,
Air Nostrum,
Air China
empresas.